Multi-Scale Modeling of Patient-Specific Ventricular Geometry, Fiber Structure, and Biomechanics

Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology.

Patient-specific modeling of ventricular electrophysiology requires an interpolated reconstruction of the 3-dimensional (3D) geometry of the patient ventricles from the low-resolution (Lo-res) clinical images. The goal of this study was to implement a processing pipeline for obtaining the interpolated reconstruction, and thoroughly evaluate the efficacy of this pipeline in comparison with alter...

Patient-Specific Skeletal Muscle Fiber Modeling from Structure Tensor Field of Clinical CT Images

We propose an optimization method for estimating patientspecific muscle fiber arrangement from clinical CT. Our approach first computes the structure tensor field to estimate local orientation, then a geometric template representing fiber arrangement is fitted using a Bspline deformation by maximizing fitness of the local orientation using a smoothness penalty. The initialization is computed wi...

Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts

Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease,...

Patient-specific isogeometric analysis for vascular biomechanics

Isogeometric Analysis (IGA) has recently emerged as a cost-effective alternative to classic isoparametric Finite Element Analysis. In this work a novel computational framework is proposed in order to get IGA-suitable geometries to simulate different vascular minimally-invasive procedures. The preliminary results show the capability of the framework to import in a straightforward way patient-spe...

Patient-specific Modeling of Cardiac Biomechanics in Repaired Tetralogy of Fallot